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HomeChemistryEnvironment friendly Bi-enzymatic synthesis of aldonic acids

Environment friendly Bi-enzymatic synthesis of aldonic acids


Aldonic acids have already discovered many purposes in meals, pharmaceutical, and cosmetics industries and there are a lot of new ones prone to come. One of many limiting elements, which stalls additional analysis and makes use of of this broad class of sugar acids, is an absence of environment friendly and environmentally pleasant manufacturing strategies. Right here we report a novel bi-enzymatic thionine-mediated PQQ-dependent glucose dehydrogenase and heme peroxidase system that permits environment friendly manufacturing of aldonic acids. Structurally numerous aldoses, together with mono-, di-, and oligosaccharides, might be oxidized this technique to the corresponding aldonic acids. The response proceeds below gentle circumstances – water resolution and ambient temperature. Because of the whole turnover variety of PQQ-dependent dehydrogenase reaching 3.5 × 106 (for lactose), the developed technique could be very environment friendly. This permits an area–time yield as much as 11 g (L h)−1 (for xylose), making the general course of industrially enticing.

Graphical abstract: Efficient Bi-enzymatic synthesis of aldonic acids

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