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Basement membrane mechanical properties


Extrinsic forces have an underestimated affect on shaping tissues and organs. Extracellular matrixes encompass tissues and supply the cells with mechanical stimuli to drive morphogenetic processes.  A specialised extracellular matrix (ECM) that’s essential for the event of epithelial tissues and organs is the basement membrane. The composition of this matrix varies from tissue to tissue and may encompass a whole bunch of distinct proteins. Nonetheless, 4 important elements are current in practically each basement membrane throughout metazoan life: Laminins, a household of heterotrimeric (α,β,γ) glycoproteins, that self-assemble into networks and work together with cell floor receptors like integrins or dystroglycans. Collagen IV is a triple-stranded helical construction forming networks by covalent interactions. Nidogen is a sulfated glycoprotein that’s supposed to attach Laminin and Collagen IV and Perlecan, a heparan sulfate proteoglycan that’s concerned in cell-signaling by binding of a number of progress components.

To what extent the presence of those important elements is interdependent through the upkeep of basement membranes and to what extent particular person elements contribute to the mechanical properties of basement membranes just isn’t nicely understood.

Ovariole with Drosophila egg chambers of distinct phases (2-8).

On this Concern of Growth (Growth (2022) 149 (10)) we handle these questions and present that Laminin and Collagen IV networks partially persist independently from one another and measured the mechanical properties of the basement membrane after knock-down of single important elements.

https://doi.org/10.1242/dev.200456

Reference

Uwe Töpfer, Karla Yanín Guerra Santillán, Elisabeth Fischer-Friedrich, Christian Dahmann; Distinct contributions of ECM proteins to basement membrane mechanical properties in DrosophilaGrowth 15 Could 2022; 149 (10): dev200456. doi: https://doi.org/10.1242/dev.200456

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